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Front Cover: Chemoenzymatic Halocyclization of γ,δ‐Unsaturated Carboxylic Acids and Alcohols (ChemSusChem 1/2020)
Author(s) -
Younes Sabry H. H.,
Tieves Florian,
Lan Dongming,
Wang Yonghua,
Süss Philipp,
Brundiek Henrike,
Wever Ron,
Hollmann Frank
Publication year - 2020
Publication title -
chemsuschem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201903373
Subject(s) - front cover , catalysis , biocatalysis , chemistry , halide , organic chemistry , vanadium , reusability , combinatorial chemistry , cover (algebra) , reaction mechanism , computer science , engineering , software , programming language , mechanical engineering
The Front Cover shows the vanadium‐dependent haloperoxidase from the marine organism Curcuvaria inaequalis ( Ci VCPO). Ci VCPO efficiently activates halides as hypohalites, which then initiate spontaneous halo‐lactonization and halo‐etherification reactions. The general applicability is demonstrated by various examples. The outstanding catalytic activity and robustness of Ci VCPO make it a very efficient catalysts for this reaction. More than 6000 g product was obtained per gram biocatalyst. An E‐factor analysis demonstrates the potential and highlights points of attention towards environmentally more acceptable processes. More information can be found in the Communication by S. H. H. Younes et al. on page 97 in Issue 1, 2020 (DOI: 10.1002/cssc.201902240).