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Ru‐Catalyzed Selective C(sp 3 )−H Monoborylation of Amides and Esters
Author(s) -
Yao Wubing,
Yang Jianguo,
Hao Feiyue
Publication year - 2020
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201902448
Subject(s) - borylation , ruthenium , iridium , catalysis , rhodium , chemistry , environmentally friendly , selectivity , alkyl , combinatorial chemistry , aryl , boron , organic chemistry , ecology , biology
A ruthenium‐catalyzed method has been developed for the C(sp 3 )−H monoborylation of various unactivated alkyl and aryl amides and challenging esters, with a low‐cost and bench‐stable boron source, providing boronates with exclusive selectivity, high efficiency, and high turnover number (up to 8900). This novel strategy may offer a versatile and environmentally friendly alternative to current methods for selective C(sp 3 )−H borylation that employ even more expensive metals, such as iridium and rhodium.