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Front Cover: Resting Escherichia coli as Chassis for Microbial Electrosynthesis: Production of Chiral Alcohols (ChemSusChem 8/2019)
Author(s) -
Mayr Jeannine C.,
Grosch JanHendrik,
Hartmann Lena,
Rosa Luis F. M.,
Spiess Antje C.,
Harnisch Falk
Publication year - 2019
Publication title -
chemsuschem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201900931
Subject(s) - electrosynthesis , escherichia coli , chemistry , faraday efficiency , shewanella oneidensis , nad+ kinase , synthetic biology , alcohol dehydrogenase , combinatorial chemistry , stereochemistry , biochemistry , electrochemistry , bacteria , biology , alcohol , enzyme , genetics , electrode , gene , bioinformatics
The Front Cover shows Escherichia coli (E. coli) as a production chassis for microbial electrochemical synthesis. This was exemplified for the conversion of acetophenone to ( R )‐1‐phenylethanol with a stereoselectivity of >99 % ee by a heterologously expressed alcohol dehydrogenase of Lactobacillus brevis . The wiring of the NAD(P) + /NAD(P)H,H + ‐ pool of E. coli to the electrode was achieved using methyl viologen, which is colorless if oxidized and deep violet in its reduced state, as mediator combined with molecular engineering using “wire” proteins from the periplasm of Shewanella oneidensis , being a model for electroactive microorganisms. This proof‐of‐concept already demonstrates a coulombic efficiency of up to 50% and a yield of approximately 40%. Thus, the work clearly lays the foundation for further microbial electrochemical synthesis of valuable pharmaceuticals and chemical building blocks. More information can be found in the Communication by J. C. Mayr et al. on page 1631 in Issue 8, 2019 (DOI: 10.1002/cssc.201900413).