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A Ball‐Milling‐Enabled Reformatsky Reaction
Author(s) -
Cao Qun,
Stark Roderick T.,
Fallis Ian A.,
Browne Duncan L.
Publication year - 2019
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201900886
Subject(s) - reformatsky reaction , zinc , mechanochemistry , ball mill , inert , chemistry , grinding , solvent , substrate (aquarium) , yield (engineering) , chemical engineering , materials science , nanotechnology , combinatorial chemistry , organic chemistry , metallurgy , oceanography , engineering , geology
An operationally simple one‐jar one‐step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre‐activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39–82 % yield) and is effective irrespective of the initial morphology of the zinc source.