Premium
Continuous‐Flow Visible Light Organophotocatalysis for Direct Arylation of 2 H ‐Indazoles: Fast Access to Drug Molecules
Author(s) -
Vidyacharan Shinde,
Ramanjaneyulu Bandaru T.,
Jang Seungwook,
Kim DongPyo
Publication year - 2019
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201900736
Subject(s) - eosin y , microreactor , visible spectrum , combinatorial chemistry , homogeneous , chemistry , continuous flow , flow chemistry , molecule , photocatalysis , nanotechnology , photochemistry , catalysis , materials science , organic chemistry , optoelectronics , physics , mechanics , thermodynamics
A continuous‐flow homogeneous photocatalytic method has been devised for the direct arylation of 2 H ‐indazoles. This visible‐light‐promoted approach directly accesses a wide range of structurally diverse C3‐arylated scaffolds of biological interest in a fast (1 min), single‐step reaction by using eosin Y as an organophotocatalyst. Furthermore, a microreactor technology is also employed for the fast synthesis of liver X receptor inhibitor drugs with very good yields under metal‐free conditions, whereas the reported methods required multiple steps and much longer reaction times (18–24 h).