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Redox‐Neutral Decarbonylative Cross‐Couplings Coming of Age
Author(s) -
Zhao Qun,
Szostak Michal
Publication year - 2019
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201900408
Subject(s) - electrophile , decarbonylation , trifluoromethylation , nucleophile , chemistry , aryl , redox , combinatorial chemistry , coupling reaction , carboxylic acid , photochemistry , catalysis , computational chemistry , organic chemistry , alkyl , trifluoromethyl
Major progress has recently been made in the challenging redox‐neutral decarbonylative cross‐coupling of carboxylic acids. For example, the use of acid fluorides as effective cross‐coupling partners has been found to enable control of the decarbonylation selectivity and facilitates challenging Pd 0 ‐catalyzed nucleophilic trifluoromethylation and exogenous base‐free Suzuki cross‐coupling reactions. In another recent advance, the use of acid chlorides in room temperature difluoromethylation and direct decarbonylative cross‐coupling of carboxylic acids allows these classical substrates to be used as aryl electrophiles in cross‐coupling reactions. Further challenges that are yet to be addressed in redox‐neutral decarbonylative cross‐couplings are also briefly summarized.