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Coolade. A Low‐Foaming Surfactant for Organic Synthesis in Water
Author(s) -
Lee Nicholas R.,
CortesClerget Margery,
Wood Alex B.,
Lippincott Daniel J.,
Pang Haobo,
Moghadam Farbod A.,
Gallou Fabrice,
Lipshutz Bruce H.
Publication year - 2019
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201900369
Subject(s) - pulmonary surfactant , chemistry , chemical engineering , engineering , biochemistry
Several types of reduction reactions in organic synthesis are performed under aqueous micellar‐catalysis conditions (in water at ambient temperature), which produce a significant volume of foam owing to the combination of the surfactant and the presence of gas evolution. The newly engineered surfactant “Coolade” minimizes this important technical issue owing to its low‐foaming properties. Coolade is the latest in a series of designer surfactants specifically tailored to enable organic synthesis in water. This study reports the synthesis of this new surfactant along with its applications to gas‐involving reactions.