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Rh III ‐Catalyzed Asymmetric Transfer Hydrogenation of α‐Methoxy β‐Ketoesters through DKR in Water: Toward a Greener Procedure
Author(s) -
He Bin,
Zheng LongSheng,
Phansavath Phannarath,
RatovelomananaVidal Virginie
Publication year - 2019
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201900358
Subject(s) - transfer hydrogenation , sodium formate , chemistry , formic acid , triethylamine , catalysis , rhodium , formate , kinetic resolution , asymmetric hydrogenation , carbonylation , organic chemistry , medicinal chemistry , enantioselective synthesis , carbon monoxide , ruthenium
The asymmetric reduction of α‐methoxy β‐ketoesters through transfer hydrogenation with a new rhodium(III) complex was developed. The reaction was efficient in 2‐MeTHF with formic acid/triethylamine or in water with sodium formate. The corresponding syn α‐methoxy β‐hydroxyesters were obtained with high diastereoselectivities and excellent levels of enantioselectivity through a dynamic kinetic resolution process.