Rh III ‐Catalyzed Asymmetric Transfer Hydrogenation of α‐Methoxy β‐Ketoesters through DKR in Water: Toward a Greener Procedure | Zendy

He Bin | Zendy; Zheng LongSheng | Zendy; Phansavath Phannarath | Zendy; RatovelomananaVidal Virginie | Zendy

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Rh III ‐Catalyzed Asymmetric Transfer Hydrogenation of α‐Methoxy β‐Ketoesters through DKR in Water: Toward a Greener Procedure

Author(s) -

He Bin,

Zheng LongSheng,

Phansavath Phannarath,

RatovelomananaVidal Virginie

Publication year - 2019

Publication title -

chemsuschem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.412

H-Index - 157

eISSN - 1864-564X

pISSN - 1864-5631

DOI - 10.1002/cssc.201900358

Subject(s) - transfer hydrogenation , sodium formate , chemistry , formic acid , triethylamine , catalysis , rhodium , formate , kinetic resolution , asymmetric hydrogenation , carbonylation , organic chemistry , medicinal chemistry , enantioselective synthesis , carbon monoxide , ruthenium

The asymmetric reduction of α‐methoxy β‐ketoesters through transfer hydrogenation with a new rhodium(III) complex was developed. The reaction was efficient in 2‐MeTHF with formic acid/triethylamine or in water with sodium formate. The corresponding syn α‐methoxy β‐hydroxyesters were obtained with high diastereoselectivities and excellent levels of enantioselectivity through a dynamic kinetic resolution process.

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