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Synthesis of Quinolines Through Acceptorless Dehydrogenative Coupling Catalyzed by Rhenium PN(H)P Complexes
Author(s) -
Wei Duo,
Dorcet Vincent,
Darcel Christophe,
Sortais JeanBaptiste
Publication year - 2019
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201802636
Subject(s) - rhenium , chemistry , catalysis , quinoline , annulation , alcohol , combinatorial chemistry , organic chemistry , medicinal chemistry
A practical and sustainable synthesis of substituted quinolines was achieved through the annulation of 2‐aminobenzyl alcohol with various secondary alcohols, ketones, aldehydes, or nitriles, under hydrogen‐borrowing conditions. Under the catalysis of well‐defined rhenium complexes bearing tridentate diphosphinoamino ligands, the reaction proceeded efficiently (31 examples were isolated with yields up to 96 %) affording a variety of quinoline derivatives.
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