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Urban Particulate Matter‐Induced Decomposition of S ‐Nitrosoglutathione Relevant to Aberrant Nitric Oxide Biological Signaling
Author(s) -
Oszajca Maria,
Wądołek Anna,
Hooper James,
Brindell Małgorzata,
van Eldik Rudi,
Stochel Grażyna
Publication year - 2019
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201802201
Subject(s) - s nitrosoglutathione , nitric oxide , chemistry , particulates , ascorbic acid , decomposition , oxide , glutathione , metal , inorganic chemistry , environmental chemistry , metal ions in aqueous solution , nitric acid , biochemistry , organic chemistry , food science , enzyme
Exposure to airborne particulate matter (PM) is associated with hazardous effects on human health. Soluble constituents of PM may be released in biological fluids and disturb the precisely tuned nitric oxide signaling processes. The influence of aqueous extracts from two types of airborne urban PM (SRM 1648a, a commercially available sample, and KR PM2.5, a sample collected “in‐house” in Krakow, Poland) on the stability of S ‐nitrosoglutathione (GSNO) was investigated. The particle interfaces had no direct effect on the studied reaction, but extracts obtained from both samples facilitated NO release from GSNO. The effectiveness of NO release was significantly affected by glutathione (GSH) and ascorbic acid (AscA). Examination of the combined influence of Cu 2+ , Fe 3+ , and reductants on GSNO stability revealed copper to be the main GSNO decomposing species. Computational models of nitrosothiols interacting with metal oxide substrates and solvated metal ions support these claims. The study stresses the importance of the interplay between metal ions and biological reductants in S ‐nitrosothiols decomposition.