Premium
Reactions of Disulfides with Silyl Phosphites to Generate Thiophosphates Under Neat Conditions
Author(s) -
Zhan Zhen,
Yang Zhongzhen,
Ma Dena,
Zhang Hao,
Shi Yuesen,
Wang Qiantao,
Deng Yong,
Hai Li,
Wu Yong
Publication year - 2018
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201800236
Subject(s) - chemistry , silylation , catalysis , trimethylsilyl , sulfur , solvent , reaction conditions , compatibility (geochemistry) , metal , combinatorial chemistry , coupling reaction , organic chemistry , base (topology) , chemical engineering , mathematical analysis , mathematics , engineering
Abstract An efficient procedure for the synthesis of thiophosphates is described. Without using any metallic catalyst or base, the direct sulfur–phosphorus coupling reaction of disulfides and dialkyl trimethylsilyl phosphite (DTSP) was carried out under solvent‐free reaction conditions in moderate to excellent yields with good functional group compatibility. The reaction conditions represent an advance over established methods not only in omitting the need for expensive catalysts or solvents, but also in shortening the reaction time significantly.These transformations are easy to conduct and can be readily applied to gram‐scale preparation.