Premium
Polycyclization Enabled by Relay Catalysis: One‐Pot Manganese‐Catalyzed C−H Allylation and Silver‐Catalyzed Povarov Reaction
Author(s) -
Chen ShiYong,
Li Qingjiang,
Liu XuGe,
Wu JiaQiang,
Zhang ShangShi,
Wang Honggen
Publication year - 2017
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201700452
Subject(s) - catalysis , chemistry , manganese , atom economy , cycloaddition , stereoselectivity , substrate (aquarium) , combinatorial chemistry , synergistic catalysis , cascade reaction , organic chemistry , medicinal chemistry , polymer chemistry , oceanography , geology
In this study, a Mn I /Ag I ‐based relay catalysis process is described for the one‐pot synthesis of polycyclic products by a formal [3+2] and [4+2] cycloaddition reaction cascade. A manganese(I) complex catalyzed the first example of directed C−H allylation with allenes, setting the stage for an in situ Povarov cyclization catalyzed by silver(I). The reaction proceeds with high bond‐forming efficiency (three C−C bonds), broad substrate scope, high regio‐ and stereoselectivity, and 100 % atom economy.