Polycyclization Enabled by Relay Catalysis: One‐Pot Manganese‐Catalyzed C−H Allylation and Silver‐Catalyzed Povarov Reaction | Zendy

Chen ShiYong | Zendy; Li Qingjiang | Zendy; Liu XuGe | Zendy; Wu JiaQiang | Zendy; Zhang ShangShi | Zendy; Wang Honggen | Zendy

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Polycyclization Enabled by Relay Catalysis: One‐Pot Manganese‐Catalyzed C−H Allylation and Silver‐Catalyzed Povarov Reaction

Author(s) -

Chen ShiYong,

Li Qingjiang,

Liu XuGe,

Wu JiaQiang,

Zhang ShangShi,

Wang Honggen

Publication year - 2017

Publication title -

chemsuschem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.412

H-Index - 157

eISSN - 1864-564X

pISSN - 1864-5631

DOI - 10.1002/cssc.201700452

Subject(s) - catalysis , chemistry , manganese , atom economy , cycloaddition , stereoselectivity , substrate (aquarium) , combinatorial chemistry , synergistic catalysis , cascade reaction , organic chemistry , medicinal chemistry , polymer chemistry , oceanography , geology

In this study, a Mn I /Ag I ‐based relay catalysis process is described for the one‐pot synthesis of polycyclic products by a formal [3+2] and [4+2] cycloaddition reaction cascade. A manganese(I) complex catalyzed the first example of directed C−H allylation with allenes, setting the stage for an in situ Povarov cyclization catalyzed by silver(I). The reaction proceeds with high bond‐forming efficiency (three C−C bonds), broad substrate scope, high regio‐ and stereoselectivity, and 100 % atom economy.

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