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MechanoAPI‐ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis
Author(s) -
Martins Inês C. B.,
Oliveira M. Conceição,
Diogo Hermínio P.,
Branco Luís C.,
Duarte M. Teresa
Publication year - 2017
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201700153
Subject(s) - mechanochemistry , ionic liquid , chemistry , green chemistry , solvent , nanotechnology , materials science , combinatorial chemistry , organic chemistry , chemical engineering , catalysis , engineering
Abstract An alternative, efficient, and green synthetic strategy for the preparation of pharmaceutical ionic liquids using mechanochemistry (MechanoAPI‐ILs) is reported. Six new API‐ILs based on gabapentin and l ‐glutamic acid were successfully synthesized and characterized, demonstrating that mechanochemistry is a very promising synthetic strategy. Results compare both the new and the classical approach and clearly show the advantages of the new method. This new technique is faster, solvent free, reproducible, selective, and leads to higher yields.