Premium
Synthesis of Monoalkyl Glyceryl Ethers by Ring Opening of Glycidol with Alcohols in the Presence of Lewis Acids
Author(s) -
Cucciniello Raffaele,
Ricciardi Maria,
Vitiello Rosa,
Di Serio Martino,
Proto Antonio,
Capacchione Carmine
Publication year - 2016
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201600989
Subject(s) - glycidol , chemistry , catalysis , lewis acids and bases , organic chemistry , selectivity , lewis acid catalysis , ring (chemistry) , combinatorial chemistry
The present work deals with the production of monoalkyl glyceryl ethers (MAGEs) through a new reaction pathway based on the reaction of glycidol and alcohols catalyzed by Lewis acid‐based catalysts. Glycidol is quantitatively converted with high selectivity (99 %) into MAGEs under very mild reaction conditions (80 °C and 0.01 mol % catalyst loading) in only 1 h using Al(OTf) 3 or Bi(OTf) 3 as catalyst. The proposed method enhances the choice of possible green synthetic approaches for the production of value‐added products such as MAGEs.