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Glycerol as a Building Block for Prochiral Aminoketone, N ‐Formamide, and N ‐Methyl Amine Synthesis
Author(s) -
Dai Xingchao,
Rabeah Jabor,
Yuan Hangkong,
Brückner Angelika,
Cui Xinjiang,
Shi Feng
Publication year - 2016
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201600972
Subject(s) - formamides , glycerol , formamide , chemistry , catalysis , aminoketone , organic chemistry , amine gas treating , green chemistry , enantiomer , enantiomeric excess , enantioselective synthesis , combinatorial chemistry , reaction mechanism
Prochiral aminoketones are key intermediates for the synthesis of optically active amino alcohols, and glycerol is one of the main biomass‐based alcohols available in industry. In this work, glycerol was catalytically activated and purposefully converted with amines to generate highly valuable prochiral aminoketones, as well as N ‐formamides and N ‐methyl amines, over CuNiAlO x catalyst. The catalyst structure can be anticipated as nano‐Ni species on or in CuAlO x via the formation of nano‐ Cu−Ni alloy particles. This concept may present a novel and valuable methodology for glycerol utilization.