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Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2‐Oxazolidinones, and Benzoxazolones
Author(s) -
Mancuso Raffaella,
Raut Dnyaneshwar S.,
Della Ca' Nicola,
Fini Francesco,
Carfagna Carla,
Gabriele Bartolo
Publication year - 2015
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201500343
Subject(s) - catalysis , carbonylation , ionic liquid , tetrafluoroborate , chemistry , solvent , combinatorial chemistry , oxidative phosphorylation , organic chemistry , crystallization , carbon monoxide , biochemistry
The direct syntheses of ureas, oxamides, 2‐oxazolidinones, and benzoxazolones by the oxidative carbonylation of amines, β‐amino alcohols, and 2‐aminophenols allows us to obtain high value added molecules, which have a large number of important applications in several fields, from very simple building blocks. We have found that it is possible to perform these transformations using the PdI 2 /KI catalytic system in an ionic liquid, such as 1‐butyl‐3‐methylimidazolium tetrafluoroborate, as the solvent, the solvent/catalyst system can be recycled several times with only a slight loss of activity, and the product can be recovered easily by crystallization.