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Methyl N ‐Phenyl Carbamate Synthesis from Aniline and Methyl Formate: Carbon Recycling to Chemical Products
Author(s) -
Yalfani Mohammad S.,
Lolli Giulio,
Müller Thomas E.,
Wolf Aurel,
Mleczko Leslaw
Publication year - 2015
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201402827
Subject(s) - carbamate , aniline , chemistry , methyl formate , formate , organic chemistry , green chemistry , medicinal chemistry , catalysis , reaction mechanism
Methyl N ‐phenyl carbamate was synthesized from aniline by using methyl formate as a green and efficient carbonylating agent. High yields were obtained at milder reaction conditions compared to the conventional CO/CH 3 OH route. Studies on the reaction sequence led to suggest an alternative and more efficient route to the carbamate via formanilide as intermediate.