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Using Aqueous Ammonia in Hydroaminomethylation Reactions: Ruthenium‐Catalyzed Synthesis of Tertiary Amines
Author(s) -
Wu Lipeng,
Fleischer Ivana,
Zhang Min,
Liu Qiang,
Franke Robert,
Jackstell Ralf,
Beller Matthias
Publication year - 2014
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201402626
Subject(s) - chemistry , catalysis , ruthenium , tertiary amine , ligand (biochemistry) , imidazole , aqueous solution , domino , amination , organic chemistry , ammonia , combinatorial chemistry , homogeneous catalysis , biochemistry , receptor
Abstract The direct synthesis of tertiary amines from ammonia and olefins is presented. Using a combination of Ru 3 (CO) 12 and 2‐phosphino‐substituted imidazole ligand as catalyst system allows for hydroaminomethylation reactions of bulk aliphatic and functionalized olefins. Tertiary amines are obtained in an atom‐efficient domino process in moderate to good isolated yields (45–76 %) with excellent regioselectivities ( n / iso up to 99:1).