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Direct α‐Alkylation of Ketones with Alcohols in Water
Author(s) -
Xu Guoqiang,
Li Qiong,
Feng Jiange,
Liu Qiang,
Zhang Zuojun,
Wang Xicheng,
Zhang Xiaoyun,
Mu Xindong
Publication year - 2014
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201300815
Subject(s) - alkylation , chemistry , catalysis , acetone , organic chemistry , ketone , aqueous solution , butanol , primary (astronomy) , ethanol , alcohol , physics , astronomy
The direct α‐alkylation of ketones with alcohols has emerged as a new green protocol to construct CC bonds with H 2 O as the sole byproduct. In this work, a very simple and convenient Pd/C catalytic system for the direct α‐alkylation of ketones with primary alcohols in pure water is developed. Based on this catalytic system, aqueous mixtures of dilute acetone, 1‐butanol, and ethanol (mimicking ABE fermentation products) can be directly transformed into C 5 –C 11 or longer‐chain ketones and alcohols, which are precursors to fuels.