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Efficient Formation of Benzylic Quaternary Centers via Palladium Catalysis
Author(s) -
Gottumukkala Aditya L.,
Suljagic Jasmin,
Matcha Kiran,
de Vries Johannes G.,
Minnaard Adriaan J.
Publication year - 2013
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201300276
Subject(s) - catalysis , palladium , chemistry , combinatorial chemistry , bipyridine , organic chemistry , crystal structure
Four′s a crowd: An efficient protocol for the formation of benzylic quaternary centers via arylation of enones using a catalyst made from Pd(O 2 CCF 3 ) 2 and 2,2′‐bipyridine is developed. For cyclic substrates, catalyst loadings as low as 1 mol % Pd are enough to afford excellent yields (>90 %) using a variety of arylboronic acids. In case of acyclic substrates, the addition of KSbF 6 was found to improve conversions and yields.