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Continuous‐Flow Synthesis of Adipic Acid from Cyclohexene Using Hydrogen Peroxide in High‐Temperature Explosive Regimes
Author(s) -
Damm Markus,
Gutmann Bernhard,
Kappe C. Oliver
Publication year - 2013
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201300197
Subject(s) - adipic acid , microreactor , hydrogen peroxide , tungstic acid , catalysis , chemistry , flow chemistry , computer science , chemical engineering , process engineering , combinatorial chemistry , nanotechnology , organic chemistry , materials science , engineering
Safe only in a microreactor! The synthesis of adipic acid from cyclohexene by tungstic acid‐catalyzed oxidation using hydrogen peroxide following the classical Noyori protocol can be accomplished in good yields with residence times as short as 20 min at 140 °C using a safe and scalable microreactor environment. Under these intensified conditions the use of a phase‐transfer catalyst is not required.