Premium
Acid‐Catalyzed Hydration of Alkynes in Aqueous Microemulsions
Author(s) -
Nairoukh Zackaria,
Avnir David,
Blum Jochanan
Publication year - 2013
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201200838
Subject(s) - microemulsion , catalysis , aqueous solution , regioselectivity , chemistry , organic chemistry , combinatorial chemistry , aqueous medium , pulmonary surfactant , biochemistry
Terminal aromatic alkynes are converted rapidly into ketones in a regioselective manner by treatment of their microemulsions with 0.33 M mineral acid between 80 and 140 °C. Internal and aliphatic acetylenes are likewise hydrated, but require longer reaction periods. The products are easily isolated from the reaction mixtures by phase separation. Replacement of H 2 O by D 2 O leads to the formation of trideuteriomethyl ketones.