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Enamine Catalysis in Flow with an Immobilized Peptidic Catalyst
Author(s) -
Arakawa Yukihiro,
Wennemers Helma
Publication year - 2013
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201200740
Subject(s) - enamine , catalysis , combinatorial chemistry , continuous flow , chemistry , flow chemistry , computer science , enantioselective synthesis , service (business) , nanotechnology , organic chemistry , biochemical engineering , materials science , business , engineering , marketing
Pep talk: An immobilized peptidic catalyst achieves more than 600 turnovers in a continuous‐flow system, allowing the production of chiral γ‐nitroaldehydes with excellent stereoselectivities on a scale of >450 mmol (>100 g). Such a high efficiency opens the way for more practical applications of enamine catalysis.