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Selective Synthesis of 1‐ O ‐Alkyl(poly)glycerol Ethers by Catalytic Reductive Alkylation of Carboxylic Acids with a Recyclable Catalytic System
Author(s) -
Sutter Marc,
Dayoub Wissam,
Métay Estelle,
Raoul Yann,
Lemaire Marc
Publication year - 2012
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201200447
Subject(s) - chemistry , alkylation , catalysis , alkyl , yield (engineering) , glycerol , carboxylic acid , selectivity , organic chemistry , combinatorial chemistry , materials science , metallurgy
(Poly)glycerol monoethers were synthesized in good yield and selectivity by the catalytic reductive alkylation of glycerol, diglycerol, and triglycerol with readily available, cheap and/or bio‐sourced carboxylic acids. The reaction was catalyzed by 1 mol % of Pd/C under 50 bar H 2 using an acid ion‐exchange resin as a recyclable cocatalyst. The catalytic system was recycled several times, and a mechanism is proposed for this transformation.