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An Efficient and Convenient Palladium Catalyst System for the Synthesis of Amines from Allylic Alcohols
Author(s) -
Banerjee Debasis,
Jagadeesh Rajenahally V.,
Junge Kathrin,
Junge Henrik,
Beller Matthias
Publication year - 2012
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201200247
Subject(s) - allylic rearrangement , catalysis , chemistry , palladium , amination , regioselectivity , combinatorial chemistry , organic chemistry , aryl , alkyl , enantioselective synthesis
A novel catalyst system for efficient amination of allylic alcohols with aryl and alkyl amines is presented. By applying a convenient combination consisting of Pd(OAc) 2 /1,10‐phenanthroline, a variety of allylic alcohols reacted smoothly to give the corresponding secondary and tertiary amines in good to excellent yields with high regioselectivity. The usefulness of our protocol is demonstrated in the one‐step synthesis of the antifungal drug naftifine and the calcium channel blocker flunarizine.