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TEMPO‐Mediated Electrooxidation of Primary and Secondary Alcohols in a Microfluidic Electrolytic Cell
Author(s) -
HillCousins Joseph T.,
Kuleshova Jekaterina,
Green Robert A.,
Birkin Peter R.,
Pletcher Derek,
Underwood Toby J.,
Leach Stuart G.,
Brown Richard C. D.
Publication year - 2012
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201100601
Subject(s) - electrolyte , primary (astronomy) , alcohol oxidation , chemistry , microfluidics , aqueous solution , butanol , alcohol , electrochemistry , inorganic chemistry , electrocatalyst , ethanol , chemical engineering , organic chemistry , electrode , nanotechnology , materials science , physics , astronomy , engineering
A general procedure for the 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO)‐mediated electrooxidation of primary and secondary alcohols modified for application in a microfluidic electrolytic cell is described. The electrocatalytic system utilises a buffered aqueous tert ‐butanol reaction medium, which operates effectively without the requirement for additional electrolyte, providing a mild protocol for the oxidation of alcohols to aldehydes and ketones at ambient temperature on a laboratory scale. Optimisation of the process is discussed along with the oxidation of 15 representative alcohols.