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Highly Efficient Heterogeneous Gold‐catalyzed Direct Synthesis of Tertiary and Secondary Amines from Alcohols and Urea
Author(s) -
He Lin,
Qian Yue,
Ding RanSheng,
Liu YongMei,
He HeYong,
Fan KangNian,
Cao Yong
Publication year - 2012
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201100581
Subject(s) - catalysis , urea , chemistry , heterogeneous catalysis , organic chemistry , combinatorial chemistry
Urea, the white gold: The efficient synthesis of tertiary and secondary amines is achieved by heterogeneous gold‐catalyzed direct amination of stoichiometric alcohols with urea in good to excellent yields. Via a hydrogen autotransfer pathway, the reactions of primary alcohols with urea give tertiary amines exclusively, while secondary alcohols selectively afford secondary amines.