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Sequential Continuous Flow Processes for the Oxidation of Amines and Azides by using HOF⋅MeCN
Author(s) -
McPake Christopher B.,
Murray Christopher B.,
Sandford Graham
Publication year - 2012
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201100423
Subject(s) - continuous flow , acetonitrile , chemistry , flow chemistry , combinatorial chemistry , flow (mathematics) , organic chemistry , catalysis , biochemical engineering , geometry , mathematics , engineering
The generation and use of the highly potent oxidising agent HOF ⋅ MeCN in a controlled single continuous flow process is described. Oxidations of amines and azides to corresponding nitrated systems by using fluorine gas, water and acetonitrile by sequential gas–liquid/liquid–liquid continuous flow procedures are reported.