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Ritter Reactions in Flow
Author(s) -
Audiger Logan,
Watts Kevin,
Elmore Simon C.,
Robinson Richard I.,
Wirth Thomas
Publication year - 2012
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201100372
Subject(s) - ritter reaction , carbocation , chemistry , microreactor , sulfuric acid , flow chemistry , combinatorial chemistry , organic chemistry , catalysis
Flow me a Ritter: Ritter reactions are performed in a simple microreactor setup using tert ‐butylacetate as versatile carbocation source. The protocol avoids the handling of large amounts of hot concentrated sulfuric acid as low concentrations are optimal for rapid access tert ‐butyl‐ or diphenylmethyl‐protected amides.