Premium
Solid‐Supported Gallium Triflate: An Efficient Catalyst for the Three‐Component Ketonic Strecker Reaction
Author(s) -
Wiles Charlotte,
Watts Paul
Publication year - 2012
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201100370
Subject(s) - catalysis , trifluoromethanesulfonate , chemistry , yield (engineering) , gallium , lewis acids and bases , heterogeneous catalysis , strecker amino acid synthesis , coupling reaction , organic chemistry , homogeneous catalysis , combinatorial chemistry , materials science , enantioselective synthesis , metallurgy
In light of the growing interest in the use of rare earth metal triflates as water‐tolerant Lewis acid catalysts, we embarked upon the development of a solid‐supported gallium triflate (PS‐Ga(OTf) 2 ) derivative as a means of increasing the cleanliness and cost effectiveness of using these increasingly expensive catalytic materials in synthetic processes. Having previously highlighted the advantages associated with coupling solid‐supported catalysis and the emerging area of micro‐reaction technology, we screened PS‐Ga(OTf) 2 for activity towards the ketonic Strecker reaction, in which the target α‐aminonitriles were obtained in higher yield and purity compared to reactions reported in literature, in which the analogous homogeneous catalyst was used.