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Separation of Reaction Product and Palladium Catalyst after a Heck Coupling Reaction by means of Organic Solvent Nanofiltration
Author(s) -
Tsoukala Anna,
Peeva Ludmila,
Livingston Andrew G.,
Bjørsvik HansRené
Publication year - 2012
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201100355
Subject(s) - nanofiltration , membrane , catalysis , heck reaction , acetone , solvent , chemistry , membrane technology , palladium , chemical engineering , flow chemistry , organic chemistry , polymer chemistry , biochemistry , engineering
Abstract Organic solvent nanofiltration (OSN) is a recently commercialized technology, which we have used to develop a method for the separation of a target product and the Pd catalyst from a Heck coupling postreaction mixture. The experimental setup included commercially available polyimide copolymer membranes with molecular weight cut‐off (MWCO) values in the range of 150–300 Da, acetone as the solvent, and a working pressure (N 2 ) of 3 MPa. The investigation of the membranes revealed that a membrane with a MWCO of 200 Da provided quantitative retention of the Pd catalyst and quantitative recovery of the target product by means of a cross‐flow dia‐nanofiltration procedure.