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Ionic Liquid Catalysed Synthesis of β‐Hydroxy Ketones
Author(s) -
Karmee Sanjib Kumar,
Hanefeld Ulf
Publication year - 2011
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201100083
Subject(s) - ionic liquid , chemistry , catalysis , tetrafluoroborate , ammonium hydroxide , hydroxide , inorganic chemistry , yield (engineering) , choline , sulfate , organic chemistry , materials science , biochemistry , metallurgy
Different acidic ionic liquids (ILs; namely, 1‐methylimidazolium tetrafluoroborate, 1‐methylimidazolium trifluoroacetate, N ‐methyl‐2‐pyrrolidone hydrogen sulfate, N , N , N ‐trioctyl‐ n ‐butanesulfonic acid ammonium hydrogen sulfate, 1‐methyl‐3‐(3‐sulfobutyl)imidazolium hydrogen sulfate) and basic ILs (namely, 1,1,3,3‐tetramethylguanidinium lactate and choline hydroxide) were tested as catalysts for the aldol reaction. The choline hydroxide catalysed reaction gave high yield (94.3 %) and selectivity of the 4‐hydroxy‐4‐phenylbutan‐2‐one after a short reaction time (15 min) at 0 °C. This article demonstrates the potential of choline hydroxide, which is a derivative of choline and a naturally occurring water‐soluble essential nutrient, as a highly active and selective green catalyst.