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A Synthetic Metabolic Pathway for Production of the Platform Chemical Isobutyric Acid
Author(s) -
Zhang Kechun,
Woodruff Adam P.,
Xiong Mingyong,
Zhou Jun,
Dhande Yogesh K.
Publication year - 2011
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201100045
Subject(s) - isobutyric acid , biochemical engineering , metabolic engineering , production (economics) , sustainable production , chemistry , chemical industry , metabolic pathway , carbon fibers , computer science , organic chemistry , biochemistry , engineering , metabolism , economics , algorithm , composite number , macroeconomics , enzyme
G o green: Isobutyric acid is a high‐volume industrial chemical produced from non‐sustainable petroleum feedstocks and toxic materials. A synthetic metabolic pathway is constructed in E. coli to enable the biosynthesis of this compound from glucose, a renewable carbon source. The biosynthetic approach is an attractive option from both an economical and environmental point of view.