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Green Synthesis of Dimethyl Isosorbide
Author(s) -
Tundo Pietro,
Aricò Fabio,
Gauthier Guillaume,
Rossi Laura,
Rosamilia Anthony E.,
Bevinakatti Hanamanthsa S.,
Sievert Robert L.,
Newman Christoper P.
Publication year - 2010
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201000011
Subject(s) - isosorbide , chemistry , reactivity (psychology) , nucleophile , hydrogen bond , molecule , dimethyl carbonate , organic chemistry , combinatorial chemistry , catalysis , medicine , alternative medicine , pathology
A green synthetic approach for dimethyl isosorbide (DMI) with dimethylcarbonate (DMC) in the presence of a base is reported. The easy methylation of isosorbide may be due to its unique structure (which enhances the nucleophilicity of the hydroxyl groups), and to the effect of the hydrogen bonding which increases the reactivity of the molecule towards DMC.