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Organocatalytic, Asymmetric Aldol Reactions with a Sustainable Catalyst in a Green Solvent
Author(s) -
North Michael,
Pizzato Francesca,
Villuendas Pedro
Publication year - 2009
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.200900144
Subject(s) - cyclohexanone , aldol reaction , chemistry , enamine , propylene carbonate , catalysis , organic chemistry , acetone , ethylene carbonate , organocatalysis , solvent , bifunctional , carbonate , enantioselective synthesis , electrode , electrolyte , electrochemistry
Green solvents : Cyclic carbonates (ethylene and propylene carbonate) make excellent, sustainable solvents for ( S )‐proline catalyzed cross‐aldol reactions between ketones and aromatic aldehydes. With cyclohexanone as the enamine precursor, reactions in ethylene carbonate gave much better results compared to propylene carbonate, whereas with acetone as the enamine precursor, reactions in both solvents gave similar results.