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Ligand‐Free Palladium‐Catalysed Direct Arylation of Heteroaromatics Using Low Catalyst Loadings
Author(s) -
Požgan Franc,
Roger Julien,
Doucet Henri
Publication year - 2008
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.200700166
Subject(s) - palladium , chemistry , catalysis , furan , ligand (biochemistry) , aryl , thiophene , thiazole , yield (engineering) , combinatorial chemistry , dimethylacetamide , organic chemistry , medicinal chemistry , materials science , biochemistry , alkyl , receptor , solvent , metallurgy
How low can Pd go? The direct arylation of heteroaryl compounds under very low loadings of Pd(OAc) 2 as catalyst and in the absence of any added ligand proceeds in high yield. Turnover numbers up to 10 000 are observed for the coupling of activated aryl bromides with thiazole, thiophene or furan derivatives (see scheme; DMAc= N , N ‐dimethylacetamide).