Open AccessTreatment of oral lichen planus with mucoadhesive mycophenolate mofetil patch: A randomized clinical trial
Author(s) -
Samiee Negin,
Taghavi Zenuz Ali,
Mehdipour Masumeh,
Shokri Javad
Publication year - 2020
Publication title -
clinical and experimental dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.464
H-Index - 9
ISSN - 2057-4347
DOI - 10.1002/cre2.302
Subject(s) - oral lichen planus , medicine , lesion , visual analogue scale , randomized controlled trial , burning sensation , sensation , dermatology , etiology , clinical trial , gastroenterology , surgery , neuroscience , biology
Objectives Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology which is known as a premalignant disease. A complete cure has not been found for this condition. Mycophenolate mofetil (MMF) is a new drug that seems to be effective in improving OLP lesions. But there are no studies on the efficacy of mucoadhesive form of MMF in ulcerative OLP. Therefore, this study was performed to determine the therapeutic effect of MMF mucoadhesive on OLP lesions. Material and methods Twenty‐seven patients with OLP, were enrolled in two groups. All the patients were instructed to place the MMF 2% mucoadhesive on the lesion twice daily for 4 weeks. Lesion size was measured by a sterile digital caulis (mm) and the severity of burning sensation and pain by visual analogue scale (VAS; cm) at baseline and weekly follow‐ups. Results There was no significant difference in burning sensation and lesion size at Weeks 1, 2, and 3 in both groups. In Group A, at Week 4, there was significant reduction in pain and burning sensation and lesion size on both sides ( p = .048, .012). The difference in lesion size on control sides was not significant. In Group B, at Week 4, there was significant reduction in pain and burning sensation and lesion size ( p = .004). No side effects were reported by the patients. Conclusions Based on the results, 2% MMF mucoadhesive was effective in decreasing burning sensation and pain severity and ulcer size of ulcerative OLP and the effect was time‐dependent.