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New 3D Supramolecular Ag(I) Coordination Polymer Crystal Containing 2‐Quinaldic Acid Radical Biological Ligand: Crystal Structure and Anticancer Activity
Author(s) -
Wang RenShu,
Feng Jing,
Lei YiZhu,
Chen DingMei,
Lian MingLei
Publication year - 2018
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.201800065
Subject(s) - chemistry , stacking , supramolecular chemistry , hydrogen bond , monoclinic crystal system , crystallography , ligand (biochemistry) , crystal structure , stereochemistry , bridging ligand , hela , carboxylate , coordination polymer , molecule , organic chemistry , biochemistry , receptor , cell
A new coordination polymer of {[Ag(Qina)(Bpp)]·(H 2 O) 2 } n (Qina = 2‐quinolinecarboxylic‐carboxylate, Bpp = 4,4'‐trimethylenedipyridine) is successfully synthesized and the structure is determined using single crystal X‐ray diffraction. The complex is crystallized in the monoclinic system with P2 1 /c space group: Each atom of Ag(I) is chelated by one Qina group, with each Bpp ligand bridging two Ag(I) atoms to form the 1D polymer chains. Furthermore, the 3D supramolecular architecture is a costructure directed via weak stacking interactions of C–H···π and hydrogen bond. The complex shows competitive binding affinities in calf thymus DNA (ct‐DNA) interaction by fluorescence spectroscopy. In addition, the complexes’ cytotoxic activity is explored for two kinds of cancer cell lines (Hela, MCF‐7), indicating an anticancer activity and cytotoxicity. CCDC: 1553426