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Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (PIHn) method
Author(s) -
ArayaSibaja Andrea Mariela,
Soldi Valdir,
Campos Carlos Eduardo Maduro,
Cardoso Simone Gonçalves,
Cuffini Silvia Lucia
Publication year - 2016
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.201500145
Subject(s) - differential scanning calorimetry , crystallization , polyvinyl alcohol , polymer , gelatin , polymer chemistry , materials science , copolymer , acrylonitrile , solvent , scanning electron microscope , chemistry , crystallography , organic chemistry , composite material , physics , thermodynamics
The selective crystallization of progesterone polymorphs prepared by Polymer‐Induced Heteronucleation (PIHn) method was investigated. Polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), dextran, gelatin, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as heteronucleants. Crystallizations were conducted from 0.5, 10 and 40 mg mL −1 solutions in chloroform at room temperature by solvent evaporation. The samples were characterized by X‐ray powder diffraction, differential scanning calorimetry, infrared spectroscopy and scanning electron microscopy. Form 2 was obtained from 0.5 mg mL −1 solution in almost all polymers. A mixture of both polymorphs crystallized from the three concentrations on gelatine; from 10 and 40mg mL −1 on PVA and HPMC and, from 10 mg mL −1 solutions on NBR. Form 2 crystallized on HPMC was stable for three months under ambient stress conditions (40ºC and 75% RH). These results are good evidence that the tailoring of new formulations and devices with progesterone the metastable and more soluble form 2 is possible.