Premium
Determination of reactive crystallization kinetics of 5‐(difluromethoxy)‐2‐mercapto‐1H‐benzimidazole in a batch crystallizer
Author(s) -
Wang Yongli,
Ma Shuyuan,
Lv Xiaodong
Publication year - 2012
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.201100629
Subject(s) - crystallization , kinetics , benzimidazole , chemistry , nucleation , population , solubility , crystal growth , chemical engineering , nuclear chemistry , crystallography , organic chemistry , physics , demography , engineering , quantum mechanics , sociology
5‐(difluromethoxy)‐2‐mercapto‐1H‐benzimidazole (DMB) was crystallized via the reaction between sodium salt of DMB and acetic acid. In this work, we firstly measured the solubility data of DMB in binary ethanol‐water mixture at different temperatures. Then, the reactive crystallization kinetics of DMB was determined in the batch crystallizer. Based on the population balance and mass balance, the kinetics model of reactive crystallization process of DMB was established. And the nucleation rate, size‐independent crystal growth and agglomeration kernel were determined by method of classes. Finally, based on the population balance, numeric simulation was done using the above crystallization kinetics in order to verify its reliability.