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Isolation and characterization of a new polymorph of D‐sorbitol
Author(s) -
Wang Yanlei,
Gao Junyan,
Yin Qiuxiang,
Hao Hongxun
Publication year - 2012
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.201100565
Subject(s) - crystallinity , powder diffraction , polymorphism (computer science) , chemistry , sorbitol , anhydrous , raman spectroscopy , crystallography , fourier transform infrared spectroscopy , methanol , characterization (materials science) , nuclear chemistry , materials science , chemical engineering , organic chemistry , nanotechnology , biochemistry , physics , genotype , optics , gene , engineering
A new polymorph of D‐sorbitol (named as F form) was discovered in this paper. A reliable isolation method for this new polymorph was developed. Three other known polymorphs of D‐sorbitol were also prepared for comparative purpose. The new F form was analyzed and characterized by using PXRD, DSC, Raman and FTIR spectroscopy. By comparing with current polymorphs' data, it was proved that F form is a new form that was not reported in any literatures. From PXRD data, it was confirmed that the crystallinity of the new form is very high. From DSC data, it was found that the new form is less stable than any known anhydrous forms. It was also found by transformation experiments that the new F form can transform into alpha form in methanol solution through a solution mediated transformation mechanism. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)