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A modeling approach for the non‐isothermal antisolvent crystallization of a solute with weak temperature dependent solubility
Author(s) -
Widenski D. J.,
Abbas A.,
Romagnoli J. A.
Publication year - 2012
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.201100441
Subject(s) - isothermal process , crystallization , solubility , thermodynamics , context (archaeology) , chemistry , materials science , paleontology , physics , biology
Antisolvent crystallization is a crystallization technique, which is normally operated isothermally. However, non‐isothermal operation is on occasions performed for solutes that have temperature dependent solubility. This paper shows that it is beneficial to operate antisolvent crystallizers non‐isothermally even for solutes whose solubility is weakly dependent on temperature. In this context, it demonstrates the joint control of particle mean size and size distribution coefficient of variation. A non‐isothermal crystallization model‐based framework is developed for the sodium chloride‐ethanol‐water system and validated for both isothermal and non‐isothermal operations. This framework was used to systematically determine both the optimal antisolvent feed rate and temperature profiles that minimize the coefficient of variation while producing a specified mean crystal size. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)