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Growth, spectral and thermal studies of ibuprofen crystals
Author(s) -
Ramukutty S.,
Ramachandran E.
Publication year - 2012
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.201100394
Subject(s) - thermogravimetric analysis , ibuprofen , fourier transform infrared spectroscopy , crystal (programming language) , evaporation , solubility , band gap , thermal stability , chemistry , analytical chemistry (journal) , crystal growth , infrared spectroscopy , infrared , diffraction , crystallography , materials science , nuclear chemistry , optics , organic chemistry , physics , optoelectronics , computer science , programming language , medicine , pharmacology , thermodynamics
RS ‐Ibuprofen was crystallized for the first time in silica gel under suitable pH conditions by reduction of solubility method. The grown crystals were characterized by single crystal X‐ray diffraction and density measurement. The functional groups present in the crystal were identified using Fourier transform infrared spectroscopy. Optical bandgap energy of ibuprofen was estimated as 3.19(3) eV from UV‐Vis spectrum. Thermogravimetric analysis revealed that ibuprofen is thermally stable upto 102.9 °C and the initial loss of mass was due to evaporation only. Morphological study showed that the growth is prominent along b ‐axis and the prominent face is {100}. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)