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Effect of copper (II) ion against elongation behavior of amyloid β fibrils on liposome membranes
Author(s) -
Shimanouchi T.,
Onishi R.,
Kitaura N.,
Umakoshi H.,
Kuboi R.
Publication year - 2012
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.201100344
Subject(s) - liposome , fibril , membrane , chemistry , copper , lipid bilayer , biophysics , phospholipid , bilayer , elongation , ion , biochemistry , materials science , organic chemistry , metallurgy , ultimate tensile strength , biology
The fibril growth behavior of amyloid β protein (Aβ) on cell membranes is relating to the progression of Alzheimer's disease. This growth behavior of Aβ fibrils is sensitively affected by the metal ions, neurotransmitters, or bioreactive substrate. The inhibitory effect of those materials was quantitatively estimated from the viewpoints of “crystal growth”. In a bulk aqueous solution, copper (II) ion showed the strong inhibitory effect on the growth of Aβ fibrils. Meanwhile, the addition of a closed‐phospholipid bilayer membrane (liposome) could reduce the above inhibitory effect of copper (II) ion. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)