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Optimization of process parameters by Taguchi robust design method for the development of nano‐crystals of sirolimus using sonication based crystallization
Author(s) -
Gandhi P. J.,
Murthy Z. V. P.,
Pati R. K.
Publication year - 2012
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.201100329
Subject(s) - taguchi methods , zeta potential , crystallization , materials science , fourier transform infrared spectroscopy , crystal (programming language) , nano , process analytical technology , analytical chemistry (journal) , nanotechnology , chemical engineering , computer science , chemistry , chromatography , composite material , engineering , nanoparticle , programming language , bioprocess
Taguchi method is widely used by the engineers and researchers across the globe for optimization of process parameters in view of cost, economy and time. Ultrasound based sonication process was used for deriving the nano‐crystals of sirolimus in a narrow range. Seven critical process parameters with three levels were optimized with L 18 array design. Crystal size analysis with its zeta potential measured and found that the crystals derived are stable in nature. Also SEM analysis carried out to know size and shape of the crystals and found that the crystals obtained are spherical in nature. Purity of the crystals derived checked with the help of melting point, TLC and HPLC procedures. Characterization of nano‐crystals made with Fourier transform infrared spectroscopy and X‐ray diffraction analysis. Correlation between the zeta potential and crystal size has been established with the help of scientific and statistical methods. Detailed statistical analysis such as t ‐test, regression and descriptive statistics of the results has been carried out to explore further information and interactions of process parameters. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)