Premium
Application of mean‐separation‐works method to protein crystal nucleation
Author(s) -
Nanev Christo N.
Publication year - 2008
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.200711085
Subject(s) - nucleation , globular protein , crystal (programming language) , protein crystallization , nucleus , molecule , chemistry , simple (philosophy) , crystallography , surface (topology) , chemical physics , statistical physics , physics , crystallization , computer science , mathematics , organic chemistry , geometry , philosophy , epistemology , biology , programming language , microbiology and biotechnology
Using mean‐separation‐works method of Stranski and Kaischew calculations of nucleus form and energy barrier for its formation are performed for globular protein crystals. This is done on the basis of a simple model suggested for crystal nucleation of such proteins. The prerequisite for the model is the fact that strict selection of definite sticky patches on protein molecule surface is obligatory for forming crystal lattices. The calculation results are in agreement with experimental data. (© 2008 WILEY ‐VCH Verlag GmbH & Co. KGaA, Weinheim)