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Influence of solvent and crystallization method on the crystal habit of metronidazole
Author(s) -
Di Martino P.,
Censi R.,
Malaj L.,
Capsoni D.,
Massarotti V.,
Martelli S.
Publication year - 2007
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.200710908
Subject(s) - crystallization , crystal habit , acicular , differential scanning calorimetry , solvent , elongation , crystallography , polarity (international relations) , particle size , crystal (programming language) , chemistry , materials science , particle (ecology) , chemical engineering , organic chemistry , microstructure , metallurgy , thermodynamics , biochemistry , physics , programming language , oceanography , engineering , ultimate tensile strength , computer science , cell , geology
In the present study, metronidazole was crystallized in several solvents, according to both the “cooling crystallization” and the “crystallization by non‐solvent addition”. Particle properties, such as crystal habit, elongation ratio, and mean particle size, were determined by SEM analysis. Structural changes and development of polymorphic forms were excluded by both Differential Scanning Calorimetry (DSC) and X‐Ray Powder Diffractometry (XRPD). Crystal habit (and thus elongation ratio) was typically influenced by both the solvent polarity index and the crystallization method: solvents with higher polarity index tended to promote acicular or stick‐shaped crystals with a high elongation ratio, while isodimensional crystals were promoted by decreasing the polarity index, as was particle aggregation. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)