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Determination of the solid liquid interfacial energy and thereby the critical nucleus size of paracetamol in different solvents
Author(s) -
Omar Waid,
Mohnicke Mandy,
Ulrich Joachim
Publication year - 2006
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/crat.200510584
Subject(s) - supersaturation , solubility , solvent , nucleation , chemistry , methanol , critical radius , acetone , thermodynamics , hildebrand solubility parameter , surface energy , analytical chemistry (journal) , chromatography , organic chemistry , physics , geometry , mathematics , curvature
The effect of the type of solvent on the solid liquid interfacial energy was determined by performing induction time measurements of paracetamol in methanol, 1‐propanol, acetone and water at a constant supersaturation temperature of 30 °C and different levels of supersaturation (a/a*) ranging from 1.03 to 1.24. At equal supersaturation level and temperature the induction time increases with decreasing solubility whereas the solid liquid interfacial energy decreases with increasing solubility. The interfacial energy has a minimum value of 1.45 mJ/m 2 in the solvent where paracetamol has a maximum solubility (methanol) whereas it has its maximum value of 2.91 mJ/m 2 in the solvent with minimum solubility. The interfacial energy is a function of the solubility has been established. The critical radius for homogeneous nucleation was found to be minimum in the solvent of highest solubility. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)