Permanent skin discoloration possible with Daytrana patch

The Food and Drug Administration has warned that the Daytrana patch (methylphenidate transdermal system) may cause permanent skin color changes. The Daytrana patch, for attention‐deficit hyperactivity disorder, now has a new warning on the label to describe chemical leukoderma. This is a skin condition that causes the skin to lose color due to repeated exposure to specific chemical compounds. The condition is not physically harmful, but it is disfiguring. The areas of skin color loss described with the Daytrana patch ranged up to 8 inches in diameter. This condition is not thought to be reversible, which may cause emotional distress.