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In the Search for Photocages Cleavable with Visible Light: An Overview of Recent Advances and Chemical Strategies
Author(s) -
JosaCulleré Laia,
Llebaria Amadeu
Publication year - 2021
Publication title -
chemphotochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 18
ISSN - 2367-0932
DOI - 10.1002/cptc.202000253
Subject(s) - moiety , cell permeability , nanotechnology , chemistry , molecule , absorption (acoustics) , combinatorial chemistry , computer science , materials science , organic chemistry , biochemistry , composite material
Photopharmacological tools enable the precise spatiotemporal control of small molecule drugs. Amongst them, caged compounds incorporate a photolabile moiety which is released under illumination, thus liberating the active molecule. Caging groups have long been known and many chemical scaffolds have already been used in different applications. However, most of the initial examples are cleaved with UV light, which suffers from low tissue permeability and cell damage. Recently, caging groups that are released under visible light have been reported, which expand their utility. In this review, we outline the chemical strategies that have been used to increase the absorption wavelengths; we compare their photophysical properties, discuss their synthetic accessibility, and exemplify some of their biological applications.